Project 1: Biohybrid silk fibroin-based biomaterials for nervous system regeneration and repair
We have developed and patented a new technology for brain repair; for regeneration of damaged nerves; for interconnect the nervous system with electronic devices. The research is being carried out in collaboration with other Universities, Research Centers and a spin-off company and it is integrated into two already funded research projects of the Spanish Government. The candidate can address: 1) Central nervous system regeneration and repair: in vitro and in vivo studies of the effect of the stem cells, neuroprotective/ antiinflammatory factors and electromagnetic fields on the quality and timing of the neural repair (stroke, Parkinson, Alzheimer, etc. 2) Ex-vivo development of artificial nerves: development of large flexible biohybrid structures for biological communication between brain and body organs or between brain and electronic devices. Artificial nerves are modular structures developed in vitro in co-cultures with supportive cells, neural precursors and several facilitatory factors.
Project 2: Modulation of the immune system by non-invasive vagus nerve stimulation
The electrical stimulation of the vagus nerve has multiple therapeutic effects, both central (antiepileptic, antidepressive, etc.) and peripheral (cardiac, immunologic, etc.). The candidate should focus on the modulation of the responses of the immune system in cerebral ischemia and diseases of autoimmune origin. He/she will perform electrophysiological, histochemical and inmunohistochemical studies in rats and mice. Research is being carried out in collaboration with the Technical University of Vienna (Austria) and the Faculty of Medicine - University of Naples (Italy)