The objective of the CAJAL4EU project is to develop semiconductor-based biosensor technology platforms enabling in-vitro diagnostic test manufacturers to rapidly build a variety of new multi-parameter test applications in a robust, user-friendly and cost-effective way.

Compared to other biosensor technologies, the semiconductor-based biosensors, which will be developed in this project, have as key differentiator that they can be integrated with other lowcost electronics. In addition, the cost of a semiconductor biosensor can be ultra-low at high volumes.

Furthermore, label-free detection should be feasible and multiplex capabilities will allow more accuracy and mass parallelism in clinical diagnostic applications.

The biosensors will consist of a semiconductor based transducer with an interface chemistry which makes the connection to the clinical sample to be analyzed. Subsequently, capturing of bio-targets can be detected by measuring capacitive/impedance changes in the electrical signal. With on-chip detection electronics, small electrical changes can be detected within milliseconds, enabling massively parallel real-time monitoring of bio-molecule binding events. Besides the transducers, interface chemistry and spotting technologies, microfluidics, software and hardware developments (and their integration) will play a crucial role to realize fully integrated biosensor systems.

Therefore, the main deliverables of this project are the different developed technologies; sensor technology including bio-chemical functionalization, microfluidics and related hardware and software drivers. The integrated technology blocks into a generic system solution will be tested in demonstrators to proof integration, cost efficiency and biological application relevance. This will be done in close collaboration with end-users and medical companies to realize a valuable impact on the European society and economy.