Ficha de proyecto

Intelligent and reinforced tissue scaffolds for regenerative biomedicine
Calcium phosphate ceramics have been used in medicine for more than 20 years because of its similarities to bone apatite. Bone repair and regeneration occurs along its surface and porous structures permits bone ingrowths acting as a scaffold in bony tissues sites. As well as these ceramics, bioactive glasses and biocompatible polymers are widely used but all of thempresent low strength and poor fatigue resistance to be implanted as high load bearing devices.

n order to seek better ways of processing biomaterials, so that both mechanical properties and porosity could be optimized, devices have been design combining HA with other materials, however, significant amounts of the reinforcing phases are needed to achieve the desired properties, and as these parts are significantly less bioactive than HA, or bioreabsorble, the ability of the composite to form a stable interface is poor compared to HA itself.

An ideal reinforcement material would impart mechanical integrity without diminishing its properties. This project envisages the use of carbon nanotubes (CNTs) as reinforcement material for the bioactive ceramics and to use their ability as drug delivery systems of pharmacological active molecules (osteogenic, antitumoral, antiviric,…) or as smart materials (able to change their properties as a function of the medium). In relation to this, the addition of CNTs to the base composite produces a three-dimensional electrical conducting network, property as has already been reported, could be used to provide electrical stimulation and increase of cellular proliferation.
Biomaterial engineering, Materials Engineering
FP7: People
People: ERG
European Reintegration Grant