Research topic
Stroke, the major neurovascular disorder, is the 2nd most common cause of death and the 3rd most common cause of disabilities in the European Union, with a tremendous health impact. Our research lines include the study of the damage that results from stroke, the search for therapeutic and prognostic targets of this pathology. We are also focused on the development of new ways to help the brain repair itself to restore important functions.
Because of the growing age of the population, dementia is a major socio-sanitary problem affecting millions of lives, a number that will keep on increasing, and with a huge social cost. Vascular cognitive impairment and dementia (VCID), the 2nd most common cause of dementia, includes brain disorders in which cognitive impairment is attributable to cerebrovascular pathologies. In this field, our research lines are focused on the analysis of the different neuropathological substrates underlying each different type of VCID and in the identification of mechanisms and therapeutic and diagnostic targets.
Our main lines of research (in parentheses some of the most relevant papers) are:
- Role of Innate Immunity (Circulation 2007; Mol Ther 2018; Stroke 2018, 2019)
- Vascular Cognitive Impairment (eNeuro 2018; J Clin Invest 2019; FASEB J 2019)
- Role of neutrophils on stroke (Stroke 2013, 2019; Science 2014; Immunity 2019)
- Neurogenesis and stroke (FASEB J 2014; Stroke 2017; J Clin Invest 2019)
- New targets for stroke therapy (Circulation 2008; J Neurosci 2009; Circulation 2014)
- Hemorrhagic Transformation (Stroke 2016, 2017, 2018)
- Excitotoxicity (J Neurosci 2004; J Exp Med 2006; J Clin Invest 2013)
- Ischemic Tolerance and stroke (Ann Neurol 2003; J Neurosci 2004; JCBFM 2007)
See our website (https://www.ucm.es/uin) for more details.