The following research lines are active in the group. The latest publication related to each one is included as example.
- Cannabinoid signaling in neural stem cells and progenitor identity.
(Díaz-Alonso et al. CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex. Cereb Cortex. 25:2395-408 (2014).
- Neurodevelopmental alterations induced by prenatal cannabinoid exposure.
(de Salas-Quiroga et al., Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons. Proc Natl Acad Sci USA 112:13693-8 (2015)
- Involvement of the endocannabinoid system in malformations of cortical development and refractory epilepsy.
(Díaz-Alonso et al., Loss of cannabinoid CB1 receptors induces cortical migration malformations and increases seizure susceptibility. Cerebral Cortex doi: 10.1093/cercor/bhw309 (2016).
- The endocannabinoid system in adult neurogenesis.
(Campos et al., The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Int J Neuropsychopharmacology 9:1-13 (2013).
- Neuroprotection based in cannabinoid-derived drugs.
(Blázquez et al., The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death and Differentiation 22:1618-29 (2015).
Diaz-Alonso et al., VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease. Scientific Reports 19 ;6:29789 (2016).